The larger screen and higher resolution are the trends of flat panel display, resulting in a great challenge for SPICE simulation. Empyrean ALPS is the next-generation flat panel display SPICE simulation tool. It supports tens of millions of transistors with true SPICE accuracy. It utilizes a smart matrix solver, parallel processing, and memory management techniques to achieve full panel simulation. It allows users to get pixel current, crosstalk effect and dynamic IR drop result in SPICE accuracy.